KOC UNIVERSITY SCHOOL OF MEDICINE

      HEMORHEOLOGY, HEMODYNAMICS AND VASCULAR BIOLOGY LABORATORY

Dr. Ozlem Yalcin

 

Publications

 

  1. Simmonds MJ, Atac N, Baskurt OK, Meiselman HJ, Yalcin O. Erythrocyte deformability responses to intermittent and continuous subhemolytic shear stress. Biorheology, 2014 (Accepted).

  2. Yalcin O, Ortiz D, Intaglietta M, Johnson PC, Cabrales P. The fahraeus effect in arterioles: influence of systemic hematocrit on radial distribution of red cells and plasma 2014 (Under preparation).

  3. Yalcin O, Ortiz D, Tsai AG, Johnson PC, Cabrales P: Microhemodynamic aberrations created by transfusion of stored blood. Transfusion. 2014 Apr;54(4):1015-27.
  4. Yalcin O, Ortiz D, Johnson PC, Cabrales P: Relationship between microvascular blood flow and blood rheology. AJP Heart and Circ, 2014 (Epub ahead of print).
  5. Sonmez M, Ince H.Y., Yalcin O, Ajdzanovic V, Spasojevic I, Meiselman H.J. and Baskurt O.K: The effect of alcohols on red blood cell mechanical properties and membrane fluidity depends on their molecular size. Plus One, 2013. 
  6. Meram E, Yilmaz BD, Bas C, Atac N, Yalcin O, Meiselman HJ, Baskurt OK: Shear stress-induced improvement of red blood cell deformability. Biorheology, Jan 1; 50 (3):165-76, 2013.
  7. Salazar Vazquez BY, Hightower CM, Yalcin O, Acharya SA, Intaglietta M: Semisynthetic hybrid biopolymers for non-pharmacological intervention of the microcirculation. Curr Drug Metab. Jun; 14 (5):540-6, 2013.
  8. Yalcin O, Cabrales P: Increased hemoglobin oxygen affinity protects during acute hypoxia. Am J Physiol Heart Circ Physiol. Aug 1;303(3):H271-81, 2012.
  9. Messmer C, Yalcin O, Palmer AF, Cabrales P: Small-volume resuscitation from hemorrhagic shock with polymerized human serum albumin. Am J Emerg Med. Oct;30(8):1336-46, 2012.
  10. Yalcin O, Wang Q, Johnson PC, Palmer AF, Cabrales P: Plasma expander viscosity effects on red cell free-layer thickness after moderate hemodilution. Biorheology, 48(5):277-91, 2011.
  11. Hightower CW, Yalcin O, Vazquez BY, Johnson PC and Intaglietta M: Effect of plasma expander viscosity on the cell free layer. Biorheology. 2011 Jan 1; 48(2):115-25.
  12. Hightower CM, Salazar Vazquez BY, Woo Park S, Sriram K, Martini J, Yalcin O, Tsai AG, Cabrales P, Tartakovsky DM, Johnson PC, Intaglietta M: Integration of cardiovascular regulation by the blood/endothelium cell free layer. Wiley Interdiscip Rev Syst Biol Med. 2011 Jul;3(4):458-70.
  13. Ulker P, Yaras N, Yalcin O, Celik-Ozenci C, Johnson PC, Meiselman HJ and Baskurt OK: Shear stress activation of nitric oxide synthase and increased NO levels in Human red cells. Nitric Oxide. 2011 May 31; 24(4):184-91.
  14. Sriram K, Vazquez BY, Yalcin O, Johnson PC, Intaglietta M, Tartakovsky DM: The effect of small changes in hematocrit on nitric oxide transport in arterioles. Antioxid Redox Signal. 2011 Jan 15;14(2):175-85.
  15. Kim S, Ong PK, Yalcin O, Intaglietta M, Johnson PC: The cell free layer in microvascular blood flow. Biorheology 46(3):181-9, 2009.
  16. Connes P, Uyuklu M, Tripette J, Boucher JH, Beltan E, Chalabi T, Yalcin O, Chout R, Hue O, Hardy-Dessources MD, Baskurt OK: Sampling time after tourniquet removal affects erythrocyte deformability and aggregation measurements. Clinical Hemorheology and Microcirculation 41(1): 9-15, 2009.
  17. Yalcin O, Ulker P, Yavuzer U, Meiselman HJ, Baskurt OK: Nitric oxide generation by endothelial cells exposed to shear stress in glass tubes perfused with red blood cell suspensions: role of aggregation. Am J Physiol Heart Circ Physiol. 294(5):H2098-105, 2008.
  18. Toptas B, Baykal A, Isbir M, Kupesiz A, Yalcin O, Yesilipek A, Baskurt OK: L-carnitine deficiency and red blood cell mechanical impairment in b-thalassemia Major. Clinical Hemorheology and Microcirculation 35: 349-357, 2006.
  19. Ozdem SS, Yalcin O, Meiselman HJ, Baskurt OK, Usta C: The role of potassium channels in relaxant effect of levosimendan in rat small mesenteric arteries. Cardiovascular Drugs and Therapy. Apr; 20(2):123-7, 2006.
  20. Yalcin O, Aydin F, Ulker P, Uyuklu M, Gungor F, Armstrong JK, Meiselman HJ, Baskurt: Effects of red blood cell aggregation on myocardial hematocrit gradient using two approaches to increase aggregation. American Journal of Physiology 290 (Heart Circ Physiol.) H765-H771, 2006.
  21. Baskurt OK, Yalcin O, Gungor F, Meiselman HJ: Hemorheological parameters as determinants of myocardial tissue hematocrit values. Clinical Hemorheology and Microcirculation 35: 45-50, 2006.
  22. Connes P, Yalcin O, Brun J-F, Hardeman M, Baskurt OK: Point-Counterpoint Comments: In health and in a normoxic environment, VO2max is/is not limited by cardiac output and locomotor muscle blood flow. Journal of Applied Physiology 100: 2099, 2006.
  23. Yalcin O, Meiselman HJ, Armstrong JK, Baskurt OK: Effect of enhanced red blood cell aggregation on blood flow resistance in isolated-perfused guinea pig heart preparation. Biorheology 42: 511-520, 2005.
  24. Ozdem SS, Batu O, Tayfun F, Yalcin O, Meiselman HJ, Baskurt OK: The effect of morphine in rat small mesenteric arteries. Vascular Pharmacology 43: 56-61, 2005.
  25. Senturk UK, Gunduz F, Kuru O, Kocer G, Ozkaya YG, Yesilkaya A, Bor-Kucukatay M, Uyuklu M, Yalcin O, Baskurt OK: Exercise - induced oxidative stress leads hemolysis in sedentary but not trained human. Journal of Applied Physiology 99: 1434-1441, 2005.
  26. Senturk UK, Yalcin O, Gunduz F, Kuru O, Meiselman HJ, Baskurt OK: Effect of antioxidant vitamin treatment on the time course of hematological and hemorheological alterations after an exhausting exercise episode in human subjects. Journal of Applied Physiology 98: 1272-1279, 2005.
  27. Yalcin O, Uyuklu M, Armstrong JK, Meiselman HJ, Baskurt OK: Graded alterations of red blood cell aggregation influence in vivo blood flow resistance. American Journal of Physiology 287 (Heart Circ Physiol) H2644-H2650, 2004.
  28. Gurbuz N, Yalcin O, Aksu TA, Baskurt OK. The relationship between the enzyme activity, lipid peroxidation and red blood cell deformability in hemizygous and heterozygous glucose-6-phosphate dehydrogenase deficient individuals. Clinical Hemorheology and Microcirculation 31: 235-242, 2004.
  29. Yerer MB, Yapislar H, Aydogan S, Yalcin O, Baskurt O: Lipid peroxidation and deformability of red blood cells in experimental sepsis in rats: The protective effects of melatonin. Clinical Hemorheology and Microirculation 30(2):77-82, 2004.
  30. Baskurt OK, Yalcin O, Ozdem S, Armstrong JK, Meiselman HJ. Modulation of endothelial nitric oxide synthase expression by red blood cell aggregation. American Journal of Physiology 286 (Heart Circ Physiol) H222-229, 2004.
  31. Baskurt OK, Yalcin O, Uyuklu M, Armstrong JK, Meiselman HJ: Effects of red blood cell aggregation on blood flow resistance in the isolated guinea pig hind limb. In: M. Singh, S. Radhakrishnan (Eds.) Advances in Medical Diagnostic Techniques and Procedures. New Delhi: Anamaya Pubishers; 2004; pp.139-142.
  32. Baskurt OK, Yalcin O, Meiselman HJ: Hemorheology and vascular control mechanisms. Clinical Hemorheology and Microcirculation 30: 169-178, 2004.
  33. Yalcin O, Erman A, Muratli S, Bor-Kucukatay M, Baskurt OK. Time course of hemorheological alterations following heavy anaerobic exercise in untrained human subjects. Journal of Applied Physiology 94: 997-1002, 2003.
  34. Yerer MB, Aydogan S, Yapislar H, Yalcin O, Kuru O, Baskurt OK: Melatonin increases glutathione peroxidase activity and deformability of erythrocytes in septic rats. Journal of Pineal Research 35:138-139. 2003.
  35. Tugral E, Ozlem Y, Baskurt OK. Effect of donor age on the deformability of density-seperated red blood cells. Turkish Journal of Haematology 19: 303-308, 2002.
  36. Temiz A, Yalcin O, Resmi H, Baskurt OK: Can white blood cell activation be one of the major factors that affect hemorheological parameters during and after exercise? Clinical Hemorheology and Microcirculation 26(3):189-93. 2002.
  37. Hacioglu G, Yalcin O, Bor-Kucukatay M, Ozkaya G, Baskurt OK: Red blood cell rheological properties in various rat hypertension models. Clinical Hemorheology and Microcirculation 26(1):27-32, 2002.
  38. Senturk UK, Gunduz F, Kuru O, Aktekin MR, Kipmen D, Yalcin O, Bor-Kucukatay M, Yesilkaya A, Baskurt OK: Exercise-induced oxidative stress affects erythrocytes in sedentary rats but not exercise trained rats. Journal of Applied Physiology 91: 1999-2004, 2001.
  39. Baskurt OK, Bor-Kucukatay M, Yalcin O, Meiselman HJ: Aggregation behavior and electrophoretic mobility of red blood cells in various mammalian species. Biorheology 37: 417-428, 2000.
  40. Bor-Kucukatay M, Yalcin O, Meiselman HJ, Baskurt OK: Erythropoietin-induced rheological changes of rat erythrocytes. British Journal of Haematology 110: 82-88, 2000.
  41. Bor-Kucukatay M, Yalcin O, Gokalp O, Kipmen-Korgun D, Yesilkaya A, Baykal A, Ispir M, Senturk UK, Kaputlu I, Baskurt OK: Red blood cell rheological alterations in hypertension induced by chronic inhibition of nitric oxide synthesis in rats. Clinical Hemorheology and Microcirculation 22: 267-275, 2000.
  42. Yalcin O, Bor-Kucukatay M, Senturk UK, Baskurt OK: Effects of swimming exercise on red blood cell rheology in trained and untrained rats. Journal of Applied Physiology 88: 2074-2080, 2000.
  43. Baskurt OK, Bor-Kucukatay M, Yalcin O, Meiselman HJ, Armstrong JK: Standard aggregating media to test the "aggregability" of rat red blood cells. Clinical Hemorheology and Microcirculation 22: 161-166, 2000.
  44. Baskurt OK, Bor-Kucukatay M, Yalcin O: The effect of red blood cell aggregation on blood flow resistance. Biorheology 36: 447-452, 1999. 


  International Conference Presentations

  1. Kucukaksu SD, Comert S, Lazoglu I, Yalcin O, Atac N, Baskurt OK. Evaluation of In Vitro Hemolysis test with a New Implantable Centrifugal Heart Pump (Istanbul VAD). 21st Congress of the International Society of Rotary Blood Pumps ( ISRBP 2013 ), Yokohama, Japan, September 26-28, 2013.
  2. Yalcin O, Meiselman HJ, Baskurt OK: Artificial circulatory environment and blood mechanical trauma. 17th Conference of the European Society for Clinical Hemorheology and Microcirculation Pecs, Hungary July 6-9, 2013.
  3. Yalcin O, Johnson PC, Cabrales P: The effects of blood storage on microhemodynamics. 17th Conference of the European Society for Clinical Hemorheology and Microcirculation Pecs, Hungary July 6-9, 2013.
  4. Yalcin O and Cabrales P: Role of hematocrit in hemorheology in arterioles in vivo. Biomedical Engineering Society Annual Meeting; Atlanta, GA, October 24-27, 2012.
  5. Yalcin O, Johnson PC and Cabrales P: Blood storage effects on cell free layer width and local microhemodynamics after exchange isovolumic exchange transfusion. 14th International Congress of Biorheology and 7th International Conference on Clinical Hemorheology, Koc University, Istanbul, Turkey July 4-7, 2012.
  6. Yalcin O, Johnson PC and Cabrales P: Effects of plasma viscosity on the erythrocyte cell-free layer in arterioles. 14th International Congress of Biorheology and 7th International Conference on Clinical Hemorheology, Koc University, Istanbul, Turkey July 4-7, 2012.
  7. Yalcin O, Lee C, Ranu S, Jivani M, Johnson PC and Cabrales P: Effect of systemic hematocrit on blood velocity profiles in arterioles. Experimental Biology Conference; San Diego, CA, April 21-25, 2012.
  8. Yalcin O, Jivani M, Johnson PC and Cabrales P: Effects of plasma viscosity on erythrocyte cell free layer width in arterioles after moderate hemodilution. Biomedical Engineering Society Annual Meeting; Hartford, CT, October 12-15, 2011.
  9. Lee CY, Ranu S, Yalcin O, Jivani M, Johnson PC and Cabrales P: Effects of drastic changes in hematocrit in blood velocity profiles of microvessels in vivo. Biomedical Engineering Society Annual Meeting; Hartford, CT, October 12-15, 2011.
  10. Yalcin O, Jivani M, Intaglietta M, Johnson PC: Hematocrit-Dependent Red Blood Cell Exclusion and Restriction Zones are Present at the Wall of Arterioles. Biomedical Engineering Society Annual Meeting; Austin Texas, October 6-9, 2010.
  11. Gorski S, Yalcin O, Jivani M, Intaglietta M, Johnson PC: Effect of systemic hematocrit on volume flow and cell free layer width in arterioles. Experimental Biology Conference; Anaheim, CA, April 24-28, 2010.
  12. Yalcin O, Jivani M, Intaglietta M, Johnson PC: A Hematocrit-Dependent Red Blood Cell Exclusion Zone (No Fly Zone) is Present at the Wall of Arterioles. Experimental Biology Conference; Anaheim, CA, April 24-28, 2010.
  13. Johnson P.C, Yalcin O, Cabrales P, Intaglietta M: Modeling the Circulation as a Supply and Demand System. Experimental Biology Conference; New Orleans, LA, April 18-22, 2009.
  14. Yalcin O, Choi C, Chatpun S, Intaglietta M, Johnson PC: The dependence of cell-free layer thickness in arterioles on systemic hematocrit level. Experimental Biology Conference; New Orleans, LA, April 18-22, 2009.
  15. Yalcin O, Choi C, Chatpun S, Intaglietta M, Johnson PC: The dependence of cell-free layer thickness in arterioles on systemic hematocrit level. Congress of Biorheology and 6th International Conference on Clinical Hemorheology, State College, Pennsylvania, USA -July 9-13, 2008.
  16. Yalcin O, Ulker P, Yavuzer U, Meiselman HJ, Baskurt OK: Nitric oxide generation by endothelial cells exposed to shear stress generated by flowing red blood cell suspensions: role of RBC aggregation. Congress of Biorheology and 6th International Conference on Clinical Hemorheology, State College, Pennsylvania, USA -July 9-13, 2008.
  17. Yalcin O, Ulker P, Eray E, Sari R, Balci M, Baskurt OK: Investigation of whole blood viscosity in poorly controlled diabetics using a scanning capillary viscometer. 2nd Eurosummer School on Biorheology & Symposium on micro Mechanobiology of cells, Tissues and Systems. Varna , Bulgaria, 17-20 2006.
  18. Baskurt OK, Yalcin O, Gungor F, Meiselman HJ: Hemorheological parameters as determinants of myocardial tissue hematocrit values. In. Hemorheology and Hemodynamics Symposium. 13th European Conference on Clinical Hemorheology; Siena, Italy, 26-29 June 2005.
  19. Kocer G, Senturk UK, Gunduz F, Kuru O, Uyuklu M, Yalcin O, Baskurt OK: Exercise induced oxidative stress affects erythrocytes in sedendary and trained young men. 13th European Conference on Clinical Hemorheology; Siena, Italy, 26-29 June 2005.
  20. Yalcin O, Aydin F, Gungor F, Ulker P, Uyklu M, Armstrong JK, Meiselman HJ, Baskurt OK: The effect of red blood cell aggregation on myocardial tissue hematocrit gradient in the guinea pig. 12th International Congress of Biorheology and 5th International Conference on Clinical Hemorheology. Chongqing, China. 30 May-03 June 2005 (Biorheology 42: 160, 2005).
  21. Yalcin O, Senturk UK, Baskurt OK: Time course of acute hemorheological alterations following exhausting exercise episodes. 12th International Congress of Biorheology and 5th International Conference on Clinical Hemorheology. Chongqing, China. 30 May-03 June 2005 (Biorheology 42: 91, 2005).
  22. Baskurt OK, Yalcin O, Meiselmann HJ: Effect of enhanced red blood cell aggregation on blood flow resistance in isolated –perfused guinea pig heart preparation. 12th International Congress of Biorheology and 5th International Conference on Clinical Hemorheology. Chongqing, China. 30 May-03 June 2005 (Biorheology 42: 62, 2005).
  23. Baskurt OK, Yalcin O, Armstrong JK, Meiselman HJ: Experimental alterations of red blood cell aggregability. 12th International Congress of Biorheology and 5th International Conference on Clinical Hemorheology. Chongqing, China. 30 May-03 June 2005 (Biorheology 42: 35, 2005).
  24. Yalcin O, Baskurt OK, Uyuklu M, Armstrong JK, Meiselman HJ: Effects of red blood cell aggregation on blood flow resistance in the isolated Guinea Pig hind limb. II International Conference on Medical Diagnostic Techniques and procedures. Madras, India, 1-3 April 2004.
  25. Baskurt OK, Yalcin O, Meiselman HJ: The influence of red blood cell aggregation on tissue perfusion (Plenary lecture). 7th Congress of the International Society for Experimental Microsurgery, Debrecen, Hungary, 1-4 September 2004.
  26. Yalcin O, Ozdem S, Armstrong JK, Meiselman HJ and Baskurt OK. Suppressed nitric oxide mediated arterial dilation in rats with enhanced RBC aggregation. 3rd FEPS Congress; Nice, France, 28 June-2 July 2003.
  27. Yalcin O, Kuru O, Gunduz F, Senturk UK, Baskurt OK: Time Course of hemorheological alterartions after exhaustive, aerobic exercise in trained and sedentary human subjects. 12th European Conference on Clinical Hemorheology. Sofia, Bulgaria, 22-26 September 2003.
  28. Toptas B, Baykal A, Ispir M, Baskurt OK, Yalcin O: Changes in hematological parameters of B-Thalassemia with carnitine treatment. 7th International Symposium on Spin Trapping, North Carolina, USA, 7-11 July 2002 (Free Rad Biol Med 33 S1: 469, 2002).
  29. Yerer MB, Yapislar H, Yalcin O, Aydogan SS, Saraymen R, Kuru O, Baskurt OK: The protective effect of melatonin on lipid peroxidation and deformability of red blood cells in experimental sepsis in rats. 11th International Congress of Biorheology and 4rd International Conference on Clinical Hemorheology. Antalya, Turkey. 22-26 September 2002 (Biorheology 39: 693, 2002).
  30. Toptas B, Baykal A, Yalcin O, Yesilipek A, and Baskurt OK: Effects of L-carnitine on erythrocyte deformability and erythrocyte aggreagation in Beta Thalassemia. 11th International Congress of Biorheology and 4rd International Conference on Clinical Hemorheology. Antalya, Turkey. 22-26 September 2002 (Biorheology 39: 689, 2002).
  31. Yerer MB, Yapislar H, Yalcin O, Aydogan SS, Saraymen R, Kuru O, Baskurt OK: The elevated glutathione peroxidase activity by melatonin administration in endotoxemic rats and its relation to erythrocyte deformability. 11th International Congress of Biorheology and 4rd International Conference on Clinical Hemorheology. Antalya, Turkey. 22-26 September 2002 (Biorheology 39: 644, 2002).
  32. Yalcin O, Bor-Kucukatay M, Kucukatay V, Kuru O, Cirrik S, Erman A, Muratli S, Baskurt OK: The time course of hemorheological alterations after anaerobic and aerobic exercise. 11th International Congress of Biorheology and 4rd International Conference on Clinical Hemorheology. Antalya, Turkey. 22-26 September 2002 (Biorheology 39: 622, 2002).
  33. Baskurt OK, Yalcin O, Armstrong JK, Meiselman HJ, and Fischer TC: Increased arterial blood pressure in rats exchange transfused with Pluronic F98-coted RBC. 11th International Congress of Biorheology and 4rd International Conference on Clinical Hemorheology. Antalya, Turkey. 22-26 September 2002 (Biorheology 39: 614, 2002).
  34. Yalcin O, Tugral E, Erman A, Muratli S, Baskurt OK: The effects of aerobic and anaerobic exercise on red blood cell rheology. International Conference Hemorheology, Yaroslavl, Russia, 29-31 July 2001.
  35. Kuru O, Senturk UK, Gunduz F, Yalcin O, Bor-Kucukatay M, Baskurt OK: Effect of antioxidant treatment on red blood cell rheological properties in trained and sedentary rats. International Conference Hemorheology, Yaroslavl, Russia, 29-31 July 2001.
  36. Yalcin O, Tugral E, Baskurt OK: Effect of donor age on red blood cell rheological properties. International Conference on Biorheology & School for Young Scienticts. Sofia, Bulgaria, 12-22 October 2000.
  37. Kuru O, Bor-Kucukatay M, Gunduz F, Yalcin O, Senturk UK, Baskurt OK: Higher red blood cell aggregation in regularly exercising, old rats. International Conference on Biorheology & School for Young Scienticts. Sofia, Bulgaria, 12-22 October 2000.
  38. Hacioglu G, Yalcin O, Mete F, Bor-Kucukatay M, Ozkaya G, Baskurt OK: Rws blood cell rheological properties in various rat hypertension models. International Conference on Biorheology & School for Young Scienticts. Sofia, Bulgaria, 12-22 October 2000.
  39. Bor-Kucukatay M, Yalcin O, Meiselman HJ, Baskurt OK: Red blood cell aggregability after erythropoetin treatment in rats. 10th International Congress of Biorheology and 3rd International Conference on Clinical Hemorheology. Pecs, Hungary. 18-22 July 1999 (Biorheology 36: 166, 1999).
  40. Baskurt OK, Bor-Kucukatay M, Yalcin O: The effect of red blood cell aggregation on blood flow resistance. 10th International Congress of Biorheology and 3rd International Conference on Clinical Hemorheology. Pecs, Hungary. 18-22 July 1999 (Biorheology 36: 166, 1999).
  41. Yalcin O, Bor-Kucukatay M, Senturk UK, Baskurt OK: The effects of heavy, swimming exercise on red blood cell rheology in trained and untrained rats. 10th International Congress of Biorheology and 3rd International Conference on Clinical Hemorheology. Pecs, Hungary. 18-22 July 1999 (Biorheology 36: 122, 1999).
  42. Baskurt OK, Bor-Kucukatay M, Yalcin O, Meiselman HJ, Armstrong JK: Standard aggregating media to test the "aggregability" of rat red blood cells. 10th International Congress of Biorheology and 3rd International Conference on Clinical Hemorheology. Pecs, Hungary. 18-22 July 1999 (Biorheology 36: 119, 1999).
  43. Bor-Kucukatay M, Yalcin O, Kayar E, Kaputlu I, Baskurt OK: Red blood cell rheology in L-NAME-induced hypertension. 10th International Congress of Biorheology and 3rd International Conference on Clinical Hemorheology. Pecs, Hungary. 18-22 July 1999 (Biorheology 36: 95, 1999).
  44. Baskurt OK, Bor-Kucukatay M, Yalcin O, Meiselman HJ, Armstrong JK: Aggregation behavior of red blood cells in different polymer solutions: Comparative studies. In: Red cell aggregation symposium. 10th International Congress of Biorheology and 3rd International Conference on Clinical Hemorheology. Pecs, Hungary. 18-22 July 1999 (Biorheology 36: 63, 1999).