KOC UNIVERSITY SCHOOL OF MEDICINE
HEMORHEOLOGY, HEMODYNAMICS AND VASCULAR BIOLOGY LABORATORY
Research Interests
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Projects
Intracellular signaling mechanisms in the regulation of red blood cell mechanical properties
Red blood cells (RBC) have long been considered as passive
transporters of respiratory gases, owing to their extremely high
hemoglobin concentration. Their mechanical properties are
important in fulfilling this function, however these properties
were also thought to be totally resulting from the special
material properties of these simple cells. New experimental
evidence gathered in the last few years started to change this
opinion. This project is exploring the molecular signaling
pathways within RBC that take part in the active regulation of
the ability of these cells to change their shape (i.e.,
deformability). This property is known to be the determinant of
blood flow under given hemodynamic conditions. |
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Molecular and cellular
approach to erythrocyte aggregation and adhesion
The special way of
aggregation of erythrocytes (rouleaux formation) is an important
factor affecting a variety of in vivo hemodynamic processes that
influence blood flow and tissue perfusion. Despite the extensive
research the basic mechanisms for this physiological phenomena
are still not clearly understood. |
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